Journal article
Viral clearance as a surrogate of clinical efficacy for COVID-19 therapies in outpatients: a systematic review and meta-analysis
KM Elias, SR Khan, E Stadler, TE Schlub, D Cromer, MN Polizzotto, SJ Kent, T Turner, MP Davenport, DS Khoury
Lancet Microbe | ELSEVIER | Published : 2024
Abstract
Background: Surrogates of antiviral efficacy are needed for COVID-19. We aimed to investigate the relationship between the virological effect of treatment and clinical efficacy as measured by progression to severe disease in outpatients treated for mild-to-moderate COVID-19. Methods: In this systematic review and meta-analysis, we searched PubMed, Scopus, and medRxiv from database inception to Aug 16, 2023, for randomised placebo-controlled trials that tested virus-directed treatments (ie, any monoclonal antibodies, convalescent plasma, or antivirals) in non-hospitalised individuals with COVID-19. We only included studies that reported both clinical outcomes (ie, rate of disease progression ..
View full abstractGrants
Awarded by Department of Health and Aged Care, Australian Government
Funding Acknowledgements
Funding Australian Government Department of Health, Medical Research Future Fund, and Australian National Health and Medical Research Council.